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Rabu, 12 Agustus 2015

HERBAL SAPUJAGAD (Kesimpulan)

Kesimpulan

Sebagai zat yang berasal dari alam, propolis tidak memiliki komposisi kimia yang stabil dan mudah direproduksi. Dengan demikian, masalah penelitian yang serius muncul, yang menyangkut definisi komposisi lengkap dengan cara yang kredibel untuk menganalisisnya. Dengan mengesampingkan keragaman, propolis selalu menunjukkan sifat biologis yang sangat aktif. Di antara senyawa kimia yang paling signifikan yang terkandung dalam propolis Polandia adalah asam-asam fenolat (phenolic acids) dan flavonoid. Karena struktur mereka, senyawa ini menampilkan aktivitas antioksidatif tinggi. Pengujian dilakukan pada polifenol dalam propolis Polandia telah memungkinkan para ilmuwan untuk merumuskan mekanisme aktivitas polifenol dan terbukti efektif sebagai antibakteri, anti-inflamasi, anti kanker, aktivitas antiatherogenik dan agen reparatif-regeneratif sel-sel dan jaringan. Dalam mempertimbangkan aktivitas antioksidatifnya tinggi, propolis Polandia kemungkinan dapat digunakan sebagai agen terapi baru yang berhubungan dengan produk lebah alami yang sedang sangat dicari.

Propolis telah dikenal dan banyak diteliti sebagai antioksidan kuat pemulung RADIKAL BEBAS, termasuk yang dihasilkan oleh proses peradangan. Kasiat Utama Propolis adalah sebagai ANTIOKSIDAN; Melia Propolis dikemas dalam botol ukuran 6ml, 30 ml dan 55 ml, masing-masing dengan harga eceran Rp 110,000, Rp 275,000  dan Rp 440,000 per botol. Harga paket untuk menjadi member atau harga paket untuk member, paket GOLD : Rp 1,100,000 dan paket PLATINUM Rp 3,025,000 (sudah termasuk pajak penjualan 10%)Pendaftaran Rp 125,000 Pemesanan via e-mail ke mssdramaga@yahoo.com.
References

  1. K?dzia, B. Chemical composition of polish propolis. Part I. The initial period of investigations.Post. Fitoter. 2009, 1, 39–44.
  2. K?dzia, B. Chemical composition of polish propolis. Part II. New Studies. Post. Fitoter. 2009, 2,122–128.
  3. Olczyk, P.; Komosi?ska-Vassev, K.; Olczyk, K. Propolis-chemical composition, properties andapplication. Farm. Pol. 2007, 63, 1102–1107.
  4. K?dzia, B.; Ho?derna-K?dzia, E. Chemical composition of propolis in nowadays researches.Herba Pol. 1991, 38, 95–107.
  5. Khalil, M.L. Biological activity of bee propolis in health and disease. Asian Pac. J. Cancer Prev.2006, 7, 22–31.
  6. De Castro, S.L. Propolis: Biological and pharmacological activities. Ann. Rev. Biomed. Sci.2001, 3, 49–83.
  7. Hegazi, A.G.; Abd El Hady, F.K.; Abd Allah, F.A. Chemical composition and antimicrobialactivity of European propolis. Z. Naturforsch. C 2000, 55, 70–75.
  8. Bankova, V. Recent trends and important developments in propolis research. Evid. Based.Complement. Alternat. Med. 2005, 2, 29–32.
  9. Warakomska, Z.; Maciejewicz, W. Microscopic analysis of propolis from Polish regions.Apidologie 1992, 23, 277–283.
  10. Bankova, V.; de Castro, S.L.; Marcucci, M.C. Propolis: Recent advances in chemistry and plantorigin. Apidologie 2000, 31, 3–15.
  11. Geckil, H.; Ates, B.; Durmaz, G.; Erdogan, S.; Yilmaz, I. Antioxidant, Free Radical Scavengingand Metal chelating characteristics of propolis. Am. J. Biochem. Biotech. 2005, 1, 27–31.
  12. Popova, M.; Bankova, V.; Butovska, D.; Petkov, V.; Damyanova, B.; Sabatini, A.G.;Marcazzan, G.L.; Bogdanov, S. Poplar type propolis and analysis of its biologically activecomponents. Honeybee Sci. 2003, 24, 61–66.
  13. K?dzia, B.; Ho?derna-K?dzia, E. The bee products in the nutrition and supplementation.Post. Fitoter. 2006, 4, 213–221.
  14. Scheller, S.; Wilczok, T.; Imielski, S.; Król, W.; Gabry?, J.; Shani, J. Free radical scavenging byethanol extract of propolis. Int. J. Radiat. Biol. 1990, 57, 461–465.
  15. Volpi, N. Separation of flavonoids and phenolic acids from propolis by capillary zoneelectrophoresis. Electrophoresis 2004, 25, 1872–1878.
  16. Maciejewicz, W.; Daniewski, M.; Dzido, T.H.; Bal, K. GC-MS and HPLC analysis of phenolicacids extracted from propolis and from Populus Nigra bud exudate. Chem. Anal. 2002, 47, 25–29.
  17. Dobrowolski, J.W.; Vohora, S.B.; Sharma, K.; Shah, S.A.; Naqvi, S.A.; Dandiya, P.C.Antibacterial, antifungal, antiamoebic, antiinflammatory, antipyretic studies on propolis beeproducts. J. Ethnopharmacol. 1991, 35, 77–82.
  18. Sahinler, N.; Kaftanoglu, O. Natural product propolis: Chemical composition. Nat. Prod. Res.2005, 19, 183–188.
  19. Maciejewicz, W. Isolation of flavonoid aglycones from propolis by a column chromatographymethod and their identification by GC-MS and TLC methods. J. Liq. Chrom. Rel. Tech. 2001,24, 1171–1179.
  20. Ellnain-Wojtaszek, M.; H?ado?, B.; Walkowiak, A.; Kowalewski, Z. Chemical composition ofbees products and their application in therapy. Farm. Pol. 1992, 48, 1–9.
  21. Maciejewicz, W.; Daniewski, M.; Mielniczuk, Z. Gas chromatography-mass spectrometryinvestigation of propolis. Analysis of ?-steroids. Acta Polon. Pharm. 1983, 40, 251–253.
  22. Erenia, N.; Tatiana, D. The content of micro- and macroelements in propolis. Bull. USAMV-CN.Anim. Sci. Biotechnol. 2007, 63/64, 176–178.
  23. Leja, M.; Mareczek, G.; Wyzgolik, G.; Klepacz-Baniak, J.; Czeko?ska, K. Antioxidativeproperties of bee pollen in selected plant species. Food Chem. 2007, 100, 237–240.
  24. Rice-Evans, C.A.; Miller, N.J.; Paganga, G. Structure-antioxidant activity relationships offlavonoids and phenolic acid. Free Radic. Biol. Med. 1996, 20, 933–956.
  25. Budryn, G.; Nebesny, E. Structure and antioxidant properties of coffee bean polyphenols.Bromat. Chem. Toksykol. 2005, 3, 203–209.
  26. Gulcin, I. Antioxidant activity of food constituents: An overview. Arch. Toxicol. 2012, 86, 345–391.Molecules 2014, 19 95
  27. Cuvelier, M.E.; Richard, H.; Berset, C. Antioxidative activity and phenolic composition ofpilot-plant and commercial extracts of sage and rosemary. J. Am. Oil. Chem. Soc. 1996, 73,645–652.
  28. Budryn, G.; Nebesny, E. Phenolic acids—their properties, Occurrence in plant materials,Absorption and metabolism. Bromat. Chem. Toksykol. 2006, 2, 103–110.
  29. Silva, F.A.; Borges, F.; Guimaraes, C.; Lima, J.L.; Matos, C.; Reis, S. Phenolic acids andderivatives studies on the relationship among structure, radical scavenging activity andphysicochemical parameters. J. Agric. Food Chem. 2000, 48, 2122–2126.
  30. Siquet, C.; Paiva-Martins, F.; Lima, J.L.; Reis, S.; Borges, F. Antioxidant profile ofdihydroxy- and trihydroxyphenolic acids-a structure-activity relationship study. Free Radic. Res.2006, 40, 433–442.
  31. Brand-Williams, W.; Cuvelier, E.; Berset, C.M. Use of free radical method to evaluateantioxidant activity. Lebensm-Wiss. U. Technol. 1995, 28, 25–30.
  32. Gulcin, I. Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). Toxicology 2006,217, 213–220.
  33. Makarska, E.; Michalak, M. Antioxidant activity of phenolic acids of spring barley.Annal. UMCS. Sec. E 2005, 60, 263–269.
  34. Gawlik-Dziki, U. The effect of cooking on composition and antioxidant activity of phenolicacids isolated from broccoli. Annal. UMCS. Sec. E 2004, 59, 1567–1575.
  35. Cos, P.; Rajan, P.; Vedernikova, I.; Calomme, M.; Pieters, L.; Vlietinck, A.J.; Augustyns, K.;Haemers, A.; Vanden Berghe, D. In vitro antioxidant profile of phenolic acid derivatives.Free Radic. Res. 2002, 36, 711–716.
  36. Makowska-W?s, J.; Janeczko, Z. Bioavailability of plant polyphenols. Post. Fitoter. 2004, 3,126–137.
  37. Olszewska, M. Flavonoids and their use in therapy. Farm. Pol. 2003, 59, 391–402.
  38. Kohlmünzer, S. Farmakognozja, 5th ed.; PWN: Warszawa, Poland, 2003; pp. 150–156.
  39. Heim, K.E.; Tagliaferro, A.R.; Bobilya, D.J. Flavonoid antioxidants: Chemistry, metabolism andstructure-activity relationships. J. Nutr. Biochem. 2002, 13, 572–584.
  40. Lamer-Zarawska, E.; Kowal-Gierczyk, B.; Niedworok, J. Fitoterapia i leki ro?linne, 1st ed.;PZWL: Warszawa, Poland, 2007; pp. 64–71.
  41. Czeczot, H. Flawonoidy—naturalne antyoksydanty w naszej diecie [in Polish]. ?yw. Cz?ow.Metab. 2000, 27, 372–382.
  42. Mat?awska, I. Farmakognozja, 1st ed.; Wydawnictwo Naukowe AM: Pozna?, Poland, 2005;pp. 110–119.
  43. Majewska, M.; Czeczot, H. Flavonoids in prevention and therapy of diseases. Farm. Pol. 2009,65, 369–377.
  44. Tapas, A.R.; Sakarkar, D.M.; Kakde, R.B. Flavonoids as nutraceuticals: A review. Trop. J.Pharm. Res. 2008, 7, 1089–1099.
  45. Pietta, P.G. Flavonoids as antioxidants. J. Nat. Prod. 2000, 63, 1035–1042.
  46. Silva, M.; Santos, M.; Caroco, G.; Rocha, R.; Justino, G.; Mira, L. Stucture-antioxidant activityrelationships of flavonoids: A re-examination. Free Radic. Res. 2002, 36, 1219–1227.Molecules 2014, 19 96
  47. Ostrowska, J.; Skrzydlewska, E. The biological activity of flavonoids. Post. Fitoter. 2005, 3–4,71–79.
  48. Burda, S.; Oleszek, W. Antioxidant and antiradical activities of flavonoids. J. Agric. Food Chem.2001, 49, 2774–2779.
  49. Dugas, A.J.; Castaneda-Acosta, J.; Bonin, G.C.; Price, K.L.; Fischer, N.H.; Winston, G.W.Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: Structure-activityrelationships. J. Nat. Prod. 2000, 63, 327–331.
  50. Rice-Evans, C. Flavonoids and isoflavones: Absorption, Metabolism, and bioactivity.Free Radic. Biol. Med. 2004, 36, 827–828.
  51. Harborne, J.B.; Williams, C.A. Advances in flavonoid research. Phytochemistry 2000, 55, 481–504.
  52. Yao, L.H.; Jiang, Y.M.; Shi, J.; Tomas-Barberan, F.A.; Datta, N.; Singanusong, R.; Chen, S.S.Flavonoids in Food and their health benefits. Plant Foods Hum. Nutr. 2004, 59, 113–122.
  53. Mihai, C.M.; Marghitas, L.A. Antioxidant capacity of Transylvanian propolis. Anim. Sci.Biotech. 2010, 67, 266–270.
  54. Mihai, C.M.; Marghitas, L.A.; Dezmiren, D.S.; Barnutiu, L. Correlation between polyphenolicprofile and antioxidant activity of propolis from Transylvania. Animal Sci. Biotech. 2011, 44,100–103.
  55. Kurek-Górecka, A.; Sobczak, A.; Rzepecka-Stojko, A.; Górecki, M.T.; Wardas, M.;Paw?owska-Góral, K. Antioxidant activity of ethanolic fraction of Polish propolis.Z. Naturforsch. C 2012, 67, 545–550.
  56. Olczyk, P.; Ramos, P.; Berna?, M.; Komosi?ska-Vassev, K.; Stojko, J.; Pilawa, B. Application ofelectron paramagnetic resonance spectroscopy to comparative examination of different groups offree radicals in thermal injuries treated with propolis and silver sulphadiazine. Evid. BasedComplement. Alternat. Med. 2013, 2013, doi:10.1155/2013/851940.
  57. Wojtyczka, R.; Kubina, R.; Kaba?a-Dzik, A.; Bu?dak, R. Antibacterial activity of ethanol extractof propolis. Ann. Acad. Med. Siles. 2012, 66, 39–48.
  58. Wojtyczka, R.; K?pa, M.; Idzik, D.; Kubina, R.; Kaba?a-Dzik, A.; Dziedzic, A.; W?sik, T.In vitro antimicrobial activity of ethanolic extract of polish propolis against biofilm formingstaphylococcus epidermidis strains. Evid. Based Complement. Alternat. Med. 2013, 2013,doi:10.1155/2013/590703.
  59. Scheller, S.; Dworniczak, S.; Waldemar-Klimek, K.; Rajca, M.; Tomczyk, A.; Shani, J.Synergism between ethanolic extract of Propolis (EEP) and antituberculosis drugs on growth ofmycobacteria. Z. Naturforsch. C 1999, 54, 549–553.
  60. Król, W.; Scheller, S.; Shani, J.; Pietsz, G.; Czuba, Z. Synergistic effect of ethanolic extract ofpropolis and antibiotics on the growth of Staphylococcus aureus. Arzneim-Forsch. 1993, 43,607–609.
  61. Marcucci, M.C. Propolis: Chemical composition, Biological properties and therapeutic activity.Apidologie 1995, 26, 83–99.
  62. Kaba?a-Dzik, A.; Szaflarska-Stojko, E.; Wojtyczka, R.; Stojko, A.; Stojko, R.; Pacha, J.Comparative studies on the antimibrobial activity of propolis balm and silver sulphadiazineapplied to burn wounds in pigs. Bull. Vet. Inst. Pulawy. 2003, 47, 541–545.Molecules 2014, 19 97
  63. Wojtyczka, R.; Dziedzic, A.; Idzik, D.; K?pa, M.; Kubina, R.; Kaba?a-Dzik, A.; Smole?-Dzirba, J.;Stojko, A.; Sajewicz, M.; W?sik, T. Susceptibility of staphylococcus aureus clinicalisolates to propolis extract alone or in combination with antimicrobial drugs. Molecules 2013, 18,9623–9640.
  64. Stojko, J.; Juszko-Piekut, M.; Rzepecka-Stojko, A.; Stojko, R.; Mo?dzierz, A.; Olczyk, D.;Romaniuk, D.; Kasprzak, M.; Morawiec, T. Application of the preparation sepropol—in thebedsore prophylaxis and treatment. Pol. J. Environ. Stud. 2007, 16, 609–611.
  65. Bogdanov, S. Propolis: Composition, health, medicine: A review. Available online:http://www.bee-hexagon.net/en/propolis.htm (accessed on 5 September 2013).
  66. Rosa, G.M.; Mei, R.; DiCarlo, G.; Pacilio, M.; di Carlo, R. Inhibition of inducible nitric oxidesynthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci. 2001,68, 921–931.
  67. Mutoh, M.; Takashi, M.; Fukuda, K.; Komatsu, H.; Enya, T.; Masushima-Hibiya, Y.;Mutoh, H.; Sugimura, T.; Wakabayashi, K. Suppression by flavonoids of cyclooxygenase-2promoter-dependent transcriptional activity in colon cancer cells: Structure activity relationship.Jpn. J. Cancer Res. 2000, 91, 686–691.
  68. Iravani, S.; Zolfaghari, B. Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract.Res. Pharm. Sci. 2011, 6, 1–11.
  69. Borrelli, F.; Maffia, P.; Pinto, L.; Ianaro, A.; Russo, A.; Capasso, F.; Ialenti, A. Phytochemicalcompounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia 2002, 73,53–63.
  70. Rossi, A.; Ligresti, A.; Longo, R.; Russo, A.; Borrelli, F.; Sautebin, L. The inhibitory effect ofpropolis and caffeic acid phenethyl ester on cyclooxygenase activity in J774 macrophages.Phytomedicine 2002, 9, 530–535.
  71. Mirzoeva, O.K.; Calder, P.C. The effect of propolis and its components on eicosanoid productionduring the inflammatory response. Prostaglandins Leucot. Essent. Fatty Acids 1996, 55, 441–449.
  72. B?o?ska, M.; Bronikowska, J.; Pietsz, G.; Czuba, Z.P.; Scheller, S.; Krol, W. Effects of ethanolextract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages.J. Ethnopharmacol. 2004, 91, 25–30.
  73. Song, Y.S.; Park, E.H.; Hur, G.M.; Ryu, Y.S.; Kim, Y.M.; Jin, C. Ethanol extract of propolisinhibits nitric oxide synthase gene expression and enzyme activity. J. Ethnopharmacol. 2002, 80,155–161.
  74. De Almeida, E.C.; Menezes, H. Anti-inflammatory activity of propolis extracts: A review.J. Venom. Anim. Toxins. 2002, 8, 191–212.
  75. Massaro, F.C.; Brooks, P.R.; Wallace, H.M.; Russel, F.D. Cerumen of Australian stingless bees(Tetragonula carbonaria): Gas chromatography-mass spectrometry fingerprints and potentialanti-inflammatory properties. Naturwissenschaften 2011, 98, 329–337.
  76. Reis, C.M.F.; Carvalho, J.C.T.; Caputo, L.R.G.; Patrício, K.C.M. Anti-inflammatory, anti-ulcerand subchronic toxicity ethanol extract of propolis. Rev. Bras. Farmacogn. 2000, 9, 43–52.
  77. Park, E.H.; Kahng, J.H. Suppressive effects of propolis in rat adjuvant arthritis. Arch. Pharm.Res. 1999, 22, 554–558.Molecules 2014, 19 98
  78. Orsi, R.O.; Funari, S.R.C.; Soares, A.M.V.C.; Calvi, S.A.; Oliveira, S.L.; Sforcin, J.M.;Bankova, V. Immunomodulatory action of propolis on macrophage activation. J. Venom. Anim.Toxins 2000, 6, 205–219.
  79. Moura, S.A.L.; Negri, G.; Salatino, A.; Lima, L.D.C.; Dourado, L.P.A.; Mendes, J.B.;Andrade, S.P.; Ferreira, M.A.N.D.; Cara, D.C. Aqueous extract of Brazilian green propolis:Primary components, evaluation of inflammation and wound healing by using subcutaneousimplanted sponges. Evid. Based Complement. Alternat. Med. 2011, 2011, doi:10.1093/ecam/nep112.
  80. Ahmed, K.M.; Saleh, E.M.; Sayed, E.M.; Shalaby, K.A.F. Anti-Inflammatory effect of differentpropolis extracts in Thioacetamide-induced hepatotoxicity in male tat. Austral. J. Basic. Appl.Sci. 2012, 6, 29–40.
  81. Díaz-Carballo, D.; Malak, S.; Bardenheuer, W.; Freistuehler, M.; Reusch, H.P. The contributionof plukenetione A to the anti-tumoral activity of Cuban propolis. Bioorg. Med. Chem. 2008, 16,9635–9643.
  82. Benkovic, V.; Knezevic, A.H.; Dikic, D.; Lisicic, D.; Orsolic, N.; Basic, I.; Kosalec, I.; Kopjar, N.Radioprotective effects of propolis and quercetin in gamma-irradiated mice evaluated by thealkaline comet assay. Phytomedicine 2008, 15, 851–858.
  83. Lugli, E.; Ferraresi, R.; Roat, E.; Troiano, L.; Pinti, M.; Nasi, M.; Nemes, E.; Bertoncelli, L.;Gibellini, L.; Salomoni, P.; et al. Quercetin inhibits lymphocyte activation and proliferationwithout inducing apoptosis in peripheral mononuclear cells. Leuk. Res. 2009, 33, 140–150.
  84. Sánchez, Y.; Amrán, D.; Fernández, C.; de Blas, E.; Aller, P. Genistein selectively potentiatesarsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen speciesgeneration and activation of reactive oxygen species-inducible protein kinases (p38-MAPK,AMPK). Int. J. Cancer 2008, 123, 1205–1214.
  85. Zhang, Q.; Zhao, X.H.; Wang, Z.J. Cytotoxicity of flavones and flavonols to a human esophagealsquamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis.Toxicol. In Vitro 2009, 23, 797–807.
  86. Chan, W.S.; Wen, P.C.; Chiang, H.C. Structure-activity relationship of caffeic acid analogues onxanthine oxidase. Anticancer Res. 1995, 15, 703–707.
  87. Qin, W.; Zhu, W.; Shi, H.; Hewett, J.E.; Ruhlen, R.L.; MacDonald, R.S.; Rottinghaus, G.E.;Chen, Y.C.; Sauter, E.R. Soy isoflavones have an antiestrogenic effect and alter mammarypromoter hypermethylation in healthy premenopausal women. Nutr. Cancer 2009, 61, 238–244.
  88. Orsoli?, N.; Benkovi?, V.; Horvat-Knezevi?, A.; Kopjar, N.; Kosalec, I.; Bakmaz, M.;Mihaljevi?, Z.; Bendelja, K.; Basi?, I. Assessment by survival analysis of the radioprotectiveproperties of propolis and its polyphenolic compounds. Biol. Pharm. Bull. 2007, 30, 946–951.
  89. Kimoto, T.; Arai, S.; Kohguchi, M.; Aga, M.; Nomura, Y.; Micallef, M.J.; Kurimoto, M.;Mito, K. Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilianpropolis. Cancer Detec. Prev. 1998, 22, 506–515.
  90. Slavin, J.; Marquart, L.; Jakobs, D., Jr. Consumption of whole–grain food and decreased risk ofcancer: Proposed mechanisms. Cereal Foods World 2000, 45, 54–58.
  91. Ku?nicki, D. Antioxidants and cholesterol-reducing agents with antiatherogenic activitycontained in plant raw materials. Post. Fitoter. 2006, 4, 206–212.Molecules 2014, 19 99
  92. Nijveldt, R.J.; Nood, E.; Hoorn, D.E.C.; Boelens, P.G.; Norren, K.; Leeuven, P.A.M. Flavonoids:A review of probable mechanisms of action and applications. Am. J. Clin. Nutr. 2001, 74, 418–425.
  93. Li, Y.; Chen, M.; Xuan, H.; Hu, F. Effects of encapsulated propolis on blood glycemic control,lipid metabolism, and insulin resistance in type 2 diabetes mellitus rats. Evid. Based Complement.Alternat. Med. 2012, 2012, doi:10.1155/2012/981896.
  94. Fuliang, H.U.; Hepburn, H.R.; Xuan, H.; Chen, M.; Daya, S.; Radloff, S.E. Effects of propolis onblood glucose, blood lipid and free radicals in rats with diabetes mellitus. Pharmacol. Res. 2005,51, 147–152.
  95. Daleprane, J.B.; Freitas Vda, S.; Pacheco, A.; Rudnicki, M.; Faine, L.A.; Dörr, F.A.; Ikegaki, M.;Salazar, L.A.; Ong, T.P.; Abdalla, D.S. Anti-atherogenic and anti-angiogenic activities ofpolyphenols from propolis. J. Nutr. Biochem. 2012, 23, 557–566.
  96. De Lima, R.O.A.; Bazo, A.P.; Said, R.A. Modifying effect of propolis on dimethylhydrazineinducedDNA damage but not colonic aberrant crypt foci in rats. Environ. Mol. Mutagen. 2005,45, 8–16.
  97. Lio, A.; Ohguchi, K.; Maruyama, H.; Tazawa, S.; Araki, Y.; Ichihara, K.; Nozawa, Y.; Ito, M.Ethanolic extracts of Brazilian red propolis increase ABCA1 expression and promote cholesterolefflux from THP-1 macrophages. Phytomedicine 2012, 19, 383–388.
  98. Chen, T.G.; Lee, J.J.; Lin, K.H.; Shen, C.H.; Chou, D.S.; Sheu, J.R. Antiplatelet activity ofcaffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in humanplatelets. Chin. J. Physiol. 2007, 50, 121–126.
  99. Roos, T.U.; Heiss, E.H.; Schwaiberger, A.V.; Schachner, D.; Sroka, I.M.; Oberan, T.;Vollmar, A.M.; Dirsch, V.M. Caffeic acid phenethyl ester inhibits PDGF-induced proliferationof vascular smooth muscle cells via activation of p38 MAPK, HIF-1?, and heme oxygenase-1.J. Nat. Prod. 2011, 74, 352–356.
  100. Packer, L.; Rimbach, G.; Virgii, F. Antioxidant activity and biologic properties of aprocyanidin — rich extract from pine (Pinus maritime) bark, pycnogenol. Free Radic. Biol. Med.1999, 27, 704–724.
  101. Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol), a herbalmedication with a diverse clinical pharmacology. Int. J. Clin. Pharmacol. Ther. 2002, 40, 158–168.
  102. Konishi, Y. Transepithelial transport of artepillin C in intestinal Caco-2 cell monolayers.Biochim. Biophys. Acta 2005, 1713, 138–144.
  103. Yoko, K.; Keizo, U.; Kyokok, K. Anti-hypertensive effects of propolis in spontaneously hypertensive rats. Clin. Pharmacol. Physiol. 2004, 32, 29–30.
  104. Chopra, S.; Pillai, K.K.; Husain, S.Z.; Ciri, D.K. Propolis protects against doxorubicin – inducedcardiopathy in rats. Exp. Mol. Pathol. 1995, 62, 190–198.
  105. Song, Y.S.; Jin, C.; Jung, K.J.; Park, E.H. Estrogenic effects of ethanol and ether extract ofpropolis. J. Ethnopharmacol. 2002, 82, 89–95.
  106. Jung, B.; Kim, M.; Kim, H.A.; Kim, D.; Yang, J.; Her, S.; Son, Y.S. Caffeic acid phenethyl ester,a component of beehive propolis is a novel selective estrogen receptor modulator. Phytother.Res. 2010, 24, 295–300.Molecules 2014, 19 100
  107. Kao, Y.C.; Zhou, C.; Sherman, M.; Laughton, C.A.; Chen, S. Molecular basis of theinhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens:A site-directed mutagenesis study. Environ. Health Perspect. 1998, 106, 85–92.
  108. Adlercreutz, H.; Bannwart, C.; Wähälä, K.; Mäkelä, T.; Brunow, G.; Hase, T.; Arosemena, P.J.;Kellis, J.T., Jr.; Vickery, L.E. Inhibition of human aromatase by mammalian lignans andisoflavonoid phytoestrogens. J. Steroid Biochem. Mol. Biol. 1993, 44, 147–153.
  109. Jachak, S.M. Herbal drugs an antidiabetic: An overview. CRIPS 2002, 3, 9–13.
  110. Sanderson, J.; McLauchlan, R.W.; Williamson, G. Quercetin inhibits hydrogen peroxide-inducedoxidation of the rat lens. Free Radic. Biol. Med. 1999, 26, 639–645.
  111. Matsui, T.; Ebuchi, S.; Fujise, T.; Abesundara, K.J.M.; Doi, S.; Yamada, H.; Matsumoto, K.Strong antihyperglycemic effects of water-soluble fraction of Brazilian propolis and its bioactiveconstituent, 3,4,5-tri-o-caffeoylquinic acid. Biol. Pharm. Bull. 2004, 27, 1797–1803.
  112. Fuliang, H.V.; Hepburn, H.R.; Xuan, H. Effects of propolis on blood glucose, blood lipids andfree radical in rats with Diabetes mellitus. Pharmacol. Res. 2005, 51, 1255–1261.
  113. Wang, H.K.; Xia, Y.; Yang, Z.Y.; Natschke, S.L.; Lee, K.H. Recent advances in the discoveryand development of flavonoids and their analogues as antitumor and anti-HIV agents. Adv. Exp.Med. Biol. 1998, 439, 191–225.
  114. Ng, T.B.; Huang, B.; Fong, W.P.; Yeung, H.W. Anti-human immunodeficiency virus (anti-HIV)natural products with special emphasis on HIV reverse transcriptase inhibitors. Life Sci. 1997,61, 933–934.
  115. Middleton, E.J. Effect of plant flavonoids on immune and inflammatory cell function. Adv. Exp.Med. Biol. 1998, 439, 175–182.
  116. Veljkovic, V.; Mouscadet, J.F.; Veljkovic, N.; Glisic, S.; Debyser, Z. Simple criterion forselection of flavonoid compounds with anti-HIV activity. Bioorg. Med. Chem. Lett. 2007, 17,1226–1232.
  117. Ito, J.; Chang, F.R.; Wang, H.K.; Park, Y.K.; Ikegaki, M.; Kilgore, N.; Lee, K.H. Anti-AIDSagents. 48. (1) Anti-HIV activity of moronic acid derivatives and the new melliferone-relatedtriterpenoid isolated from Brazilian Propolis. J. Nat. Prod. 2001, 64, 1278–1281.
  118. Barbosa, M.H.; Zuffi, F.B.; Maruxo, H.B.; Jorge, L.L.R. Therapeutic properties of propolis fortreatment of skin lesion. Acta Paul. Enfer. 2009, 22, 318–322.
  119. Burdock, G.A. Review of the biological properits and toxocity of bee propolis. Food Chem.Toxicol. 1998, 36, 347–363.
  120. Olczyk, P.; Wisowski, G.; Komosi?ska-Vassev, K.; Stojko, J.; Klimek, K.; Olczyk, M.;Ko?ma, E.M. Propolis modifies collagen types I and III accumulation in the matrix of burnttissue. Evid. Based Complement. Alternat. Med. 2013, 2013, doi:10.1155/2013/423809.
  121. Olczyk, P.; Komosi?ska-Vassev, K.; Winsz-Szczotka, K.; Stojko, J.; Klimek, K.; Ko?ma, E.Propolis induces chondroitin/dermatan sulphate and hyaluronic acid accumulation in the skin ofburned wound. Evid. Based Complement. Alternat. Med. 2013, 2013, doi:10.1155/2013/290675.
  122. Stojko, J.; Juszko-Piekut, M.; Rzepecka-Stojko, A.; Stojko, R.; Mo?dzierz, A.; Olczyk, D.;Romaniuk, D.; Kasprzak, M.; Morawiec, T.; Paruzel, K.; et al. Clinical Study on the Use of thePropol in the Therapy of Burn Wounds. In ?rodowiskowe ?ród?a Zagro?e? Zdrowotnych, 1st ed.;Kaczor, A., Borz?cki, A., Iskra, M., Eds.; Polihymnia: Lublin, Poland, 2007; pp. 1076–1080.Molecules 2014, 19 101
  123. Scheller, S.; Ilewicz, L.; Luciak, M.; Skobidurska, D.; Stojko, A.; Matuga, W. Biologicalproperties and clinical application of propolis. IX. Experimental observation on the influence ofEEP on dental pulp regeneration. Arzneim-Forsch. 1978, 28, 289–291.
  124. Scheller, S.; Stojko, A.; Szwarnowiecka, I.; Tustanowski, J.; Obuszko, Z. Biological propertiesand clinical application of propolis. VI. Investigation of the influence of ethanol extracts ofpropolis (EEP) on cartilaginous tissue regeneration. Arzneim-Forsch. 1977, 27, 2138–2140.
  125. Buczek, E.; Stojko, A.; Zaj?c, M.; Bregu?a, S.; Olczyk, D. The case of gas gangrene in the courseof post-operative fracture proximal end of the tibia. Kwart. Ortop. 1998, 4, 441–443.
Propolis telah dikenal dan banyak diteliti sebagai antioksidan kuat pemulung RADIKAL BEBAS, termasuk yang dihasilkan oleh proses peradangan. Kasiat Utama Propolis adalah sebagai ANTIOKSIDAN; Melia Propolis dikemas dalam botol ukuran 6ml, 30 ml dan 55 ml, masing-masing dengan harga eceran Rp 110,000, Rp 275,000  dan Rp 440,000 per botol. Harga paket untuk menjadi member atau harga paket untuk member, paket GOLD : Rp 1,100,000 dan paket PLATINUM Rp 3,025,000 (sudah termasuk pajak penjualan 10%)Pendaftaran Rp 125,000 Pemesanan via e-mail ke mssdramaga@yahoo.com.

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